Pre-Symposium Workshops (SUN, May 29)

10:00-12:00 — Session 1: Multi-modality Imaging

Chairs:
Chrysoula Vraka, University of Vienna, Austria, https://radnuk.meduniwien.ac.at/nuklearmedizin/
Bertrand Kuhnast, Université Paris-Saclay, SHFJ, France
http://www.biomaps.universite-paris-saclay.fr/

Talk1: Chemical strategies to build multimodal imaging agents: a focus on PET/optical imaging agents and hyperpolarized tracers

Talk 2: Metabolic PET/MRI and hyperpolarized imaging

Talk 3: Trends in multimodality molecular imaging with optical or US modalities combined with PET

Strategies to implement multimodality imaging: i.e. monomolecular imaging agents vs sequential or cocktail injection of the imaging probes. Chemical and radiochemical challenges. Physical principles of imaging modalities (MRI and hyperpolarised MRI, optical imaging, ultrasound). Emphasis on the benefit of the different combinations. Success and potential pitfalls in such multimodality implementation.

Followed by a Q&A session and panel discussion.

13:00-14:30 — Session 2: Preclinical Imaging Study Design

Chairs:
Wissam Beaino, Tracer Center Amsterdam, Netherlands
https://research.vumc.nl/en/
Chrysoula Vraka, University of Vienna, Austria, https://radnuk.meduniwien.ac.at/nuklearmedizin/

Talk 1: Ethical aspects related to animal experiments

  • Jean Claude Desfontis, Ecole Nationale Vétérinaire Agroalimentaire et de l'Alimentation Nantes Atlantique, France, https://www.oniris-nantes.fr/

    Legislation in the use of animals for experimental purposes, such as the 3R principle, justification, ethical approval, statistics, animal number, animal housing, education and training of personnel, project authorization, and guidelines for specific procedures for handling animals.

Talk 2: Standardisation in small animal PET Imaging

Short overview about the physical principles of the considered imaging modalities (PET) and subsequent focus on reproducibility, the influence of PET results, reconstruction parameters, application route, etc., and how to standardize PET.

Talk 3: Preclinical PET imaging in neurology and oncology

Background information about the available animal models (xenografts, GEMMs, etc.) with a focus on neurology and oncology. Particular attention “hands-on” examples with established PET tracers and newly developed PET tracers including the rationality of the used animal model and imaging protocols based on the scientific question.

Followed by a Q&A session and panel discussion.

15:00-16:30 — Session 3: How to develop a successful imaging agent

Chair: Jacques Barbet, Arronax, France, https://www.arronax-nantes.fr/

Fully Interactive Workshop:

Part 1: Debate around the choice of radiometals vs covalent isotopes to develop a radiotracer depending on the imaging paradigm.

Part 2: Quiz for the attendees to participate, covering the whole process of radiotracer manufacturing, the choices to make, and pitfalls to avoid.

Debaters:

Valery Radchenko, Triumf, Canada, https://www.triumf.ca/

Fabien Caillé, Université Paris-Saclay, SHFJ, France, http://www.biomaps.universite-paris-saclay.fr/

Moderators:

Sandrine Huclier, University of Nantes, France, http://www-subatech.in2p3.fr/fr/

Anthony Gee, King’s College London, UK, https://kclpure.kcl.ac.uk/portal/antony.gee.html